Variant information for all human chemokines and receptors was
gathered from >140,000 healthy individuals from the Genome
Aggregation Database (GnomAD) (Karczewski et al., 2019, Nature;
https://gnomad.broadinstitute.org).
Only missense variants were considered.
The table includes the following columns:
“protein” - chemokine or GPCR
“CCN or CRN” - common chemokine or chemokine receptor
numbering
“consequence” - variant substitution and residue number
associated with substitution (unprocessed, N-terminal numbering);
variants are listed using HGVS nomenclature https://varnomen.hgvs.org/recommendations/general/
“allele count” - number of instances in which given allele
(i.e. variant) was identified in population
“allele count” - total alleles counted at the given
position
“allele frequency” - fraction of instances in which allele
is observed relative to the total alleles counted at the given
position