chemokine & GPCR phenotype- and disease-associated
variants
Variant information for all human chemokines and receptors was
gathered for genome-wide statistical associations between variants and
disease- or phenotypic-associated traits. Associations are based on data
from ~500,000 individuals from the GeneATLAS database (made available
via UK Biobank) (Canela-Xandri et al., 2018. Nature Genetics).
Only missense variants were considered. All listed
disease-/phenotype-associated variants are below thresholds for
significance used in Canela-Xandri, et al. 2018.
The table includes the following columns:
“protein” - chemokine or GPCR
“CCN or CRN” - common chemokine or chemokine receptor
numbering
“trait ID” - trait identifier
“trait description” - trait description
“consequence” - variant substitution and residue number
associated with substitution (unprocessed, N-terminal numbering)